Topikal Uygulamalar için Antimikrobiyal Kitosan-Sodyum tetrafloroborat (NaBF4) Hidrojeller

Infection of a wound is one the most important reasons delaying recovery an injured tissue. In this study, chitosan-based hydrogels were loaded with different concentrations sodium tetrafluoroborate (NaBF4) to fabricate antimicrobial care system. Antimicrobial activity, and cytotoxicity NaBF4, surface morphology, chemical bond structures activity Chitosan:NaBF4 against broad spectrum microorganisms including antibiotic resistant species investigated. NaBF4 showed higher antibacterial for gram-positive bacteria than gram-negative bacteria. MIC values 3.906, 1.953, 7.813 µg/µL every gram-negative, gram-positive, fungal species, respectively. Direct on L929 cell line was investigated by MTT assay. IC50 value after 24 h incubation calculated as 3.2 which within range concentration activity. The activities chitosan disc diffusion method. hydrogel increased increasing while parent high molecular weight did not show According results, sample 1:3 (NaBF4 concertation 546.5mM in hydrogel) enough achieve prepared formulation can be used potential product.